Euthanasia Essays - Euthanasia, Medical Ethics, Disability Rights

Euthanasia Euthanasia, which means "good" or "peaceful" death, has been practiced through the ages. Doctors have always been dedicated to the task of easing pain and suffering, to make dying easier. Adding the adjective "active" alters the meaning of euthanasia. The emphasis shifts from comforting the dying to inducing death. The practice of voluntary euthanasia and assisted suicide would cause society to devalue all life, especially the lives of the dying, the disabled, and the elderly. We should not understate the agonies involved in chronic pain and suffering. Nobody wants to see a loved one suffer or make the decisions that accompany medical science's ability to prolong life. The same technology that keeps people alive today raise a host of questions concerning the nature and destiny of man himself. Comforting the dying is still preferable to assisting in their death. There are many reasons why, but the main one has to do with how much we value human life. God views all human life as sacred. He created us in his own image (Genesis 1:26,27), and it is he who has determined our days on earth (Job 14:5). God confirms his great love for his people, a love that does not cease when we are old or ill. His command that we not kill one another does not change when we are brain damaged or comatose. Our society, however, teaches certain classes of people that they are not wanted. If a physician's aid in dying were to become a standard part of terminal care, there is always that possibility that patients might feel the need to request death out of fear of becoming a burden to their families. The right to die could be interpreted by a patient as the duty to die. Chronically ill or dying patients may be pressured to choose euthanasia to spare their families financial or emotional strain. Joan Farah states in the New England Journal of Medicine that the elderly are often cited as being vulnerable. If Euthanasia becomes the law of the land, how long will it take before the elderly and sick begin to feel an obligation to get out of the way? There are many complicated ethical and medical issues involved in the discussion of euthanasia. The decisions that family members must make are often as painful as the conditions of their loved ones. Sometimes the families react with wisdom and compassion. However, under stress human beings can make the wrong decisions. In an attempt to avoid such risk we dare not enact legislature that will allow murder simply to make decisions easier. Opponents contend that legalized euthanasia would force medical professionals and patients' families to judge the worth of others' lives. Once a vulnerable group is denied a basic right to life, it is only a matter of time until other groups are placed in the same category. We have accepted the killing of unborn children, allowed children born with severe handicaps to die, and have ignored "mercy killing" of consenting adults. Will we tolerate or accept euthanasia just as we do abortion? There are no easy answers when a loved one faces death. Scientists must continue to seek answers and cures. Active euthanasia does not provide answers: it only tries to avoid the hardest questions. Thomas Beauchamp, a bioethicist of Georgetown University has written, rules against killing "are not isolated moral principles," but "pieces of a web of rules" that forms a moral code. "The more threads one removes the weaker the fabric becomes." Allowing ourselves the liberty of choosing the time and place of death will not lessen our sense of loss. It can only erode the wonder of human life and the worth of each individual. Wekesser, Carol, ed. Euthanasia: Opposing Viewpoints. San Diego: Greenhaven Press, 1995.

Persuasive Essay on Gun Control

Persuasive Essay on Gun Control Persuasive Essay on Gun Control English teachers encourage students to look for controversial issues in society on which to base a persuasive essay. The reason is that the teacher wants a topic that can be easily debated on either side of the issue and that brings forth strong emotions from both sides. The purpose is to help students organize and express ideas in a clear and coherent manner. One such controversial issue is gun control. One side of the argument is that the policies for owning and using guns should be stricter. One who holds such a position might argue as follows: It is very unfortunate that people are losing their loved ones due to the misuse of guns. While guns should be used to enhance security of people in a society, the same guns have been using in perpetuating crimes that have worsened the security status of many countries. In order to eradicate the issue of insecurity, guns should be used only when necessary. In this case there is a need to put in place policies that will ensure that gun use is properly controlled. In addition to this example are suggestions below on how to write a persuasive essay on gun control. Suggestions on How to Write a Persuasive Essay on Gun Control: First, determine what your position is on gun control. Next, plan the major arguments in support of your position. Be sure to offer explanations, facts and statistics, as well as examples. You can even include anecdotal material. Do not forget the â€Å"so what† factor. In other words, make certain to get the reader to see why it is important to that individual’s personal life. Secondly, when preparing a persuasive essay on gun control, the writer should explain the reason why guns are in the hands of the people. Constitutional rights can be discussed as to the original intent and modern interpretation of those rights. In addition, the writer can point out reasons why people should respect the sanctity of life and the right of every human being to be alive, regardless of ones stance on regulations involving gun control. Next, the writer can help the reader to explore whether everyone should have a right to own and operate a gun. For example, should criminals be permitted to own and use a fire arm? What about individuals with mental health issues? While every person is entitled to security, not all people should be issued guns. This is the reason why governments put into place stringent measures for applying for and purchasing weapons. Additionally, the writer can remind the reader that cooperation between civilians and the police is important in following the due process for acquiring guns. Regulations and the need for regulations can be explored in this context. Preparing a persuasive essay on gun control is not as easy as one may think. Emotions run high. On one hand is the need to protect oneself and even ones country. Furthermore, some individuals use weapons for sport, such as range shooting or hunting. However, there are safety issues where someone acts out anger or frustration by pulling a gun and shooting the other person. In addition to that are issues with criminals. Some say that guns should be better monitored to keep them out of the hands of those who would harm society, while others argue that those who break the law will obtain guns anyway. However, regardless of what side of the issue you choose to support, you will need to make your position clear and your arguments strong. Moreover, you will need to convey your ideas in a clear and compelling manner. Feel free to succeed in persuasive essay writing with !

Creative manager Essay Example | Topics and Well Written Essays - 2500 words

Creative manager - Essay Example Several financial institutions are most affected by the crisis, of which HSBC Bank is one. This paper would present pertinent issues resulting to the breakdown of the financial markets of the world and propose strategies to enable HSBC to achieve its organizational goals by: (1) briefly explaining the factors that brought about the breakdown of the global financial markets (2) determining the possible effects on the operations of HSBC in UK utilizing SWOT analyses; and (3) presenting the strategies that HSBC should adopt to achieve her vision and restore public confidence HSBC Bank has been operating in England and Wales at the registered office located at 8 Canada Square, London E14 5HQ. It offers a diverse portfolio of financial instruments including savings and current accounts, investment accounts, credit cards, loans, mortgages, insurance and international services. It supports a wide range of education projects and initiatives throughout the communities where they do business. In addition, â€Å"HSBC supports a wide range of projects and initiatives that underline their commitment to UK businesses.† (HSBC 2009) The management of HSBC promotes diversity and equality of opportunities through programs where they establish partnerships with other business organizations. Accordingly, â€Å"representatives of HSBC Bank plc can provide advice on investment and pension products from selected providers, including companies within the HSBC Group, and on life insurance products from HSBC Life (UK) Limited.† (ibid.) Jarvis (2009) gives a concise and easy to understand presentation of the credit crisis in his video The Crisis of Credit Visualized. According to Jarvis, â€Å"the credit crisis is a world wide financial fiasco involving terms you probably heard such as: sub-prime mortgages, collateralized debt obligations, frozen credit markets and credit default swaps

W3D 590 perceive people Essay Example | Topics and Well Written Essays - 250 words

W3D 590 perceive people - Essay Example These aspects may render one perceive or view people positively or negatively. They affect the way one senses certain information before showing any impression. Therefore, there are several factors that commonly incite the way we perceive people. The first one is the mood state experienced by a person (Smith, 2013). Moods affects strongly on the way we perceive someone. We are able to think properly or make a positive impression of others when we are happy compared with times when we are depressed. When in undesirable mood, we are most probably going to evaluate others unfavorably than when in a positive mood state. An interviewer will make a good recommendation about a job applicant when his or her mood state is welcoming. The second factor is the attitude of the perceiver towards someone being perceived. The attitude that we have towards others affects the impressions we make on others. For example, if a male interviewer has a negative attitude on female that they are not capable to handle the job given, then his perception of a female job applicant will automatically be affected (Chris & Peter, 2014). The third one is the interests we have. Our attention, focus mostly appears to be affected by our interests which differ from one individual to the other. What one notices in situation may differ from what the other perceives. Before the interviewer makes any impressions, he or she will consider his or her interest in the job applicant. Self-concept is another factor that affects our thinking over others.Picking up traits in others will depend on our self-concept, one with a positive self-concept will always have positive attributes of others (Collela et al, 2010). Motive also affects the way we perceive. The interviewer who has an ill motive of a job applicant with better papers than him, he feels unsecured of his position. Fearing that the applicant might take his position will affect his perception. Another factor is knowledge,

A Review On Alcoholic Detection From EEG Signals

A Review On Alcoholic Detection From EEG Signals Abstract: This review covers advances of the past decade, in the development of EEG signal processing algorithms for alcoholic detection. In recent years, various computational approaches have been proposed to detect alcoholism from EEG recordings. In this paper, we review some of those approaches, and discuss their limitations and potential In part I, an introduction to the effect of alcohol on EEG is discussed briefly. We review some of the known effects of alcohol on EEG signal in part II. Some of the exiting state of the art signal processing techniques for alcoholic detection in EEG recordings are discussed in part III. A review of various signal processing methods used to classify alcoholics and controls is done. The potential and limitation of such computational approaches are discussed in part IV. A discussion on the potential use of EEG as a biomarker for alcoholism and as a mass screening tool is also discussed .At the end of the paper, we conclude by briefly addressing the future challenges and open problems in part V. PART I Introduction Alcoholism is a social bane that is affecting the human life in all aspects. Not only it causes damage to the human brain and other organs of the body in various ways, it also brings about a lot of difficulties and discomfort to an alcoholic person in his/her social life. A lot of research has gone into finding the ill effects and the extent to which it damages the human body. Some of the harmful effects include lack of coordination between body and mind, loss of vision, imbalance in walking, incoherent speech, memory slips, depression to name a few. These effects can be observed after only a few drinks and they may vanish once the person gives up drinking. However a person who is addicted to drinking large quantities of alcohol for a long time may be affected with these effects that persist for a longer time and severely damage one or more organs of the body. The way in which alcohol affects the brain and the probable reversal of the ill effects caused by heavy drinking on the brain still remain as hot topics in alcohol research [1]. Some of the factors that determine the extent to which alcohol affects the brain are: i) quantity and how frequently a person drinks ii) the age of the subject at which the habit of drinking started and how long it is being continued iii) subjects age, education, gender, genetic predisposition and family history of alcoholism iv) possibility of prenatal exposure and the overall health condition[47]. Heavy drinking not only affects the human brain but it also damages other vital organs of the body. It is also found that females are more affected than males in the way the alcohol consumption damages the various organs of the body. For example, a few years of heavy drinking in women cause cirrhosis [48] cardiomyopathy [49] and nerve damage [50] than in alcoholic men. However, the studies on sensitivity of females brain to alcohol-induced brain damage as compared with males, have not shown any conclusive results [1]. Alcohol intake combined with poor general health condition or with severe liver disease causes damage to the human brain in an indirect manner. For example, thiamine deficiency is common in people with alcoholism which is a result of poor overall nutrition [1].  A large percentage of alcoholics suffer from thiamine deficiency and some may even develop severe brain disorders such as [51] Wernicke-Korsakoff syndrome (WKS) [52]. The symptoms of WKS include mental confusi on, oculomotor disturbances and difficulty with muscle coordination, forgetfulness and frustration and have difficulty with walking and coordination [53] . One of the organs that severely gets affected by long term alcohol consumption in large quantities is the liver. In a person with a history of heavy long-term drinking, the liver s function is to breakdown alcohol into harmless by-products and flush them out of the body. However, the liver may get damaged due to excessive alcohol intake, leading to liver cirrhosis. This condition of the liver can harm the brain, leading to a potentially fatal brain disorder called hepatic encephalopathy [54].Some of the effects of Hepatic encephalopathy are disturbances in sleep patterns, mood swings, personality changes, anxiety, depression, attention deficits, difficulty in coordination like shaking of the hands ( asterixis). In the worst case, patients may slip into coma ( hepatic coma), which can lead to death. It is indeed difficult to diagnose these effects as related to hepatic encephalopathy. New imaging techniques assist researchers to study specific regions of brain in such patients, which helps them in knowing exactly how hepatic encephalopathy progresses. The studies have confirmed that at least two toxic substances, ammonia and manganese are responsible for the development of hepatic encephalopathy. The severely damaged liver cells allow these harmful toxic products to enter the brain, which in turn harms the brain cells. Alcohol consumption during pregnancy may lead to physical, learning, and behavioural problems in the developing fetal brain. The most serious of these problems is the fetal alcohol syndrome (FAS). Children with FAS may have distinct facial features [1]. FAS infants growth may be lesser than average. They may suffer from microcephaly. In infants with this syndrome, only a fewer neurons may be present or a fewer neurons may function properly. This will lead to problems in learning and behaviour for a long term. All alcoholics do not experience the ill effects of alcohol consumption in a similar manner to the same extent. The source of the disease may be different for different patients. This makes it difficult to pinpoint any one parameter as responsible for the brain disorders found in alcoholics. That is why, one of the active areas of research is to study why some patients are vulnerable to brain deficits while others are not [55]. Most alcoholics suffering from cognitive disorder improve in the structure and functioning of the brain within a year of abstinence [56-58].This may not be true in all cases. Therefore clinicians must devise different types of treatment methods to cater to different patients. They use brain-imaging techniques to determine the course and progress of treatment over a period of time. Researchers use imaging methods such as magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), positron emission tomography (PET), and electrophysiological brain mapping. These methods provide precise and accurate information on structural, functional and biochemical changes in patients brain over time. Sometimes, two or more brain imaging methods are used together to correlate the results and monitor when a chronic alcoholic patient stops drinking and again after long periods of sobriety ,the possibility of relapse of the drinking habit in the patient [59]. The process of memorization and retrieval depend on factors such as attention and motivation [60]. MRI of brain assist the physicians to study the effects of long time abstinence from alcohol on memory and attention, as well as changes that take place when drinking habit relapses. The aim of these studies is to differentiate between the alcohol-induced permanent effects on the brain and those which are reversible with abstinence. PET imaging assists researchers to visualize, in the living brain, the damages associated with heavy alcohol consumption [61]. This also enables scientists to analyse alcohols effects on neurotransmitter systems, brain cell metabolism and blood flow within the brain. These studies on alcoholics have shown the frontal lobe disorders, which are responsible for various functions associated with learning and memory and deficits in cerebellum which controls movement and coordination. PET can also be used for monitoring the effects of alcoholism treatment on the a ffected parts of the brain and may give new directions in developing medications to rectify the chemical deficits found in the brains of people with alcohol dependence. Numerous studies have shown the ill effects of alcohol on the human brain by observing and analysing the electroencephalogram (EEG) of the alcoholic subject and compared with that of a control subject. Electroencephalography (EEG) is a simple non invasive tool that records the brains electrical signals by placing electrodes on the scalp. These signals show real-time activity as it occurs in the brain. Many studies have shown that the effect of alcohol on the human brain can be perceived by processing the recording the EEG of an alcoholic subject. The single channel EEG recordings of a control and an alcoholic subject are as shown in fig 1.It can be observed that the time series EEG data of both control and alcoholic subjects are not clearly perceptible to the bare human eye. However, with the help of certain signal processing techniques either in the time domain or frequency domain or time-frequency domain or spatial domain techniques, the latent features can be extracted to identify the effects of alcohol on the human brain. As an illustration, the PSDs of the EEG of both control and alcoholic subject are as shown in fig2. From this it is very clear that the power contained in various frequency components are different for both control and alcoholic subjects. C:UsersMUDocumentsMATLABeeg_epilep_codestime_series_data.jpg C:UsersMUDocumentsMATLABeeg_epilep_codespsd_c_a.jpg Fig 1.Time series EEG data of control Fig2. PSD plot of EEG of control and alcoholic subjects and alcoholic subjects Many alcoholic men have low amplitude of their P3 components (fig 3). P3 amplitudes in alcoholic women reduce to a lesser extent than in men. The uniqueness of the reduction in P3 component among other symptoms is that even after the patient drops the habit of drinking alcohol, this reduction in P3 persists[63].Therefore this parameter can be thought of as a biomarker for alcohol dependence rather than an effect of alcohol consumption. There are many studies conducted on the reduced P3 amplitudes of young people who are not exposed to alcohol but their fathers being alcoholics [64, 65].Therefore, P3 can be used as biomarkers to help recognizing people who may be at greatest risk for developing problems with alcohol. graph Fig 3 . P3 amplitude in control and alcoholic subjects (Courtesy:[1]) Compared to other imaging methods discussed above, electrophysiological methods such as EEG processing for detection of alcoholics has a lot to offer in terms of mobility and cost involved. Hence it can be used as a mass screening tool for the underprivileged with a history of alcoholism. PART II Effect of Alcohol on EEG recordings Studies have shown that some of the major effects of alcohol on EEG are: i) enlargement of frontal negative occipital wave component ii) increase in ventricular and sulcal CSF volumes iii) Reduction in p300 component iv)Reduction in pre frontal cortical excitability v)Reduction in the amplitude of Error related negativity vi) Binge drinking effect on ÃŽ ´ and fast ÃŽ ²waves vii) Reduction in the power of EEG signal in frontal region and enhancement of ÃŽ ¸ waves . viii) high ÃŽ ² and ÃŽ ¸ power in the resting EEG, abnormalities in eye movements, in saccadic inhibition during antisaccade tasks. These effects, however, are not always easily detectable. There tends to be a large variability from patient to patient. As a result, none of these phenomena allow at present to reliably detect the effect of alcohol at an early stage. Many recent studies have concentrated on how to improve the sensitivity of EEG for detecting alcoholism. In the following we briefly review some of these studies. A. Enlargement of frontal negative occipittal wave component Way back in 1990, Jerald Varner et al., reported a study of alcoholic organic syndrome patients using the occipital wave components of the event related potential (ERP) as an electrophysiological parameter [3]. The study was conducted on normal, Korsakoff, and alcoholic dementia patients. The frontal negative occipital wave was observed to be increased in alcoholic organic brain syndrome patients and it was concluded that it was probably due to an attention deficit, indicating a probable frontal lobe dysfunction. B. Increase in ventricular and sulcal CSF volumes Adolf Pfefferbaum et al., [4] quantified brain cerebrospinal fluid (CSF) volumes derived from computed tomography (CT) in alcoholics and controls. The results showed that the ventricular and sulcal CSF volumes in alcoholic patients were greater than was expected for their age. This also proved the previous results obtained from a similar study using CT and MRI showing greater vulnerability of the aging brain to alcohol. The absolute ventricular volumes were similar in MRI and CT, while MRI results showed larger sulcal volume estimates than the CT. It was concluded that MRI slice thickness and its resolution to partial volume effects led to this increase in sulcal volume estimate. C. Reduction in p300 component Shirley Y. Hill et al., studied the effect of alcohol on the p300 component [9] .According to this study , it was found that only patients(female) with comorbid depression had a reduced p300 amplitude ,while there was no difference in other alcoholic and control subjects(male and female) . From this study, it was also concluded that the P300 amplitude reduction seen in children prone to developing alcoholism seems to represent a delay in neuron development that normalizes as they grow into adulthood. In another similar study, Michio Hada et al., used bootstrap analysis method in which P3a current source density (CSD) maps showed distinct topographic mapping between alcoholics and control subjects in all the brain regions [10]. More sources and sinks were seen in the alcoholics than in the control subjects for P3a. The reduced P3a amplitude and sinks in alcoholics coupled with less specificity in their CSD maps, suggested disorganized less efficient functioning of the brain. This suggests a probable underlying CNS hyper excitability in alcoholics due to cortical disinhibition . D. Reduction in pre frontal cortical excitability Seppo Kahkonen et al. [13], reported the effects of alcohol on the prefrontal cortex in nine healthy subjects using transcranial magnetic stimulation (TMS) activated electroencephalogram (EEG) signals. Changes in EEG activity lasting up to 270 ms post stimulus were observed as a response to activation by TMS. The changes were observed more prominently at anterior electrodes suggesting the reduction in excitability in the prefrontal cortex due to alcohol. E. Reduction in the amplitude of Error related negativity A study by Clay B Holroyd et al., indicated that alcohol consumption reduces the amplitude of the error-related negativity (ERN)[14] component of the event related potential(ERP), a sharp negative going signal that occurs in the EEG at the instant when an incorrect motor response starts ( ie.,error commission). F. Binge drinking effect on ÃŽ ´ and fast ÃŽ ² waves Kelley E Courtney et al. evaluated the spectral power in the ÃŽ ´ and fast ÃŽ ² waves of EEG recordings of young undergraduate university students who varied in their binge drinking history [18].The aim of the study was to characterize the effects of binge drinking on central nervous system(CNS) neuroelectric activity in male and female undergraduate subjects. The EEG recordings of these subjects showed enhanced spectral power in the ÃŽ ´ (0-4 Hz) and fast- ÃŽ ² (20-35 Hz) bands for the high-binge drinkers. Although the dependence of fast- ÃŽ ² power on binge drinking still remains unclear, the change in fast- ÃŽ ² power indicates that EEG spectral pattern of high-binge drinkers is similar to that of alcoholics. This study indicated that the relative enhancement in fast- ÃŽ ² power may be used as a biomarker for potential future alcoholism even in the absence of familial alcoholism. G.Effect on ÃŽ ²,ÃŽ ¸ ,ÃŽ ³ waves ,eye movement disorders and saccadic inhibition Wu Di et al., discussed the change in the power of EEG signal in various parts of the brain after consuming alcohol , resulting in harmful effects on different parts of the brain and the body[19]. It was observed that while in the frontal region the power of the EEG signal decreased with the increase in the quantity of alcohol intake, the power of the EEG signal in central, occipital region increased. This study also revealed that while in the frontal region, the alcohol intake caused a transformation in the fast wave with decrease in the power of EEG signal, the fast wave reduced with an increase in the power of EEG signal in the central and occipital region. It was also observed that while the effect of alcohol in the frontal region indicated nerve stimulation of alcohol in this part, making drinkers to become excited after alcohol intake, in the central and occipital region, the effect of alcohol consumption led to an inhibitory action on the neuron cells, resulting in the weakeni ng of the body coordination and eyesight. Further it was noted that increase in alcohol intake resulted in ÃŽ ¸ waves generation and gradual enhancement as the subjects were in state of drowsiness and the central nervous system(CNS) of the subjects was inhibited. At the same time, ÃŽ ± and ÃŽ ² waves were seen to gradually enhance and the region of these waves expanded after consuming alcohol. The study also indicated that the correlation between parts of brain decreased gradually because the clustering of the EEG signal was separated gradually into small clusters with increased alcohol intake. From this observation, it was concluded that too much drinking may lead to the decrease of balance, stability between the parts of the brain. S. Campanella et al., [41], studied various physiological parameters such as continuous EEG, oculomotor measures, cognitive ERPs and event-related oscillations that are affected in chronic alcoholic patients compared to healthy controls. This study was aimed at identifying links between these physiological parameters, altered cognitive processes and specific clinical symptoms. The result of their study showed:(1) high beta and theta power in the resting EEG, suggesting hyperarousal of CNS (2) abnormalities in smooth pursuit eye movements, in saccadic inhibition during antisaccade tasks, and in prepulse inhibition, suggesting disturbed attention and abnormal prefrontal inhibitory cortical dysfunction; (3) decreased amplitude for cognitive ERPs situated along the continuum of information processing, suggesting that alcoholism is associated with neurophysiological deficits at the level of the sensory cortex and not only disturbances involving associative cortices and limbic structures; and (4) decreased theta, gamma and delta oscillations, suggesting cognitive disinhibition at a functional level. Ajayan Padmanabhapillai et al.,[71] investigated the early evoked gamma band response in male adolescents at high risk and at low risk groups for a visual stimulus. The results indicate that the deficient early evoked gamma band response may indicate the risk of development of alcoholism and could be a potential bio marker for future addiction to alcoholism. David A. Kareken et al., [72] used functional magnetic resonance imaging (fMRI) to determine how family history affects the brains response to subjects preferred alcoholic drink odours (AO) as compared to appetitive control odours (ApCO). This study suggested that a family history of alcoholism and brain exposure to alcohol odour in heavy drinkers differentially affect the way in which brain responds to alcohol cues. H.Whole-genome association study on EEG waves Variation in resting EEG is associated with common, complex psychiatric diseases such as alcoholism, schizophrenia and anxiety disorders although it can not be used as a diagnostic tool for any of them. Such traits appear to be dependent on the underlying molecular processes than on clinical symptoms, and points to an alternative method for the identification of genetic variation that characterize complex psychiatric disorders. Colin A. Hodgkinsona et al.,[39], performed a whole-genome association study on alpha (ÃŽ ±), beta (ÃŽ ²), and theta (ÃŽ ¸) EEG power in a Native American cohort of 322 individuals to maintain the genetic and environmental homogeneity of this population. Three genes SGIP1, ST6GALNAC3 and UGDH were nominally associated to variability of ÃŽ ¸ or ÃŽ ± power. SGIP1 was estimated to account for 8.8 % of variance in ÃŽ ¸ power and this association was replicated in US Caucasians, where it accounted for 3.5% of the variance. Bayesian analysis of prior probability of association based upon earlier linkage to chromosome 1 and enrichment for vesicle-related transport proteins established the genuineness of the association of SGIP1 with ÃŽ ¸ power. It was also found that the association of SGIP1 with alcoholism provides validation of the use of EEG as an endo phenotype for alcoholism. I.Effect of alcohol on facilitation effect The aim of this study by P. Maurage et al., [32], was to study cross modal (auditory-visual) processing while the subjects were given an emotional stimuli and specifically the auditory-visual facilitation effect. Twenty patients suffering from alcoholism, and 20 healthy controls were asked to identify the emotion (anger or happiness) displayed by auditory, visual or auditory-visual stimuli. The stimuli were designed to elicit a facilitation effect (namely, faster reaction times (RTs) for crossmodal condition than for unimodal ones).It was observed that the alcoholics showed less significant facilitation effect compared to their healthy counterparts.This lack of facilitation effect may be used as a biomarker for an impaired auditory-visual processing in alcoholics. PART III I. Signal processing techniques for detection of alcoholism in EEG signal The Electroencephalogram (EEG) is a bio signal containing information about the state of the brain. The latent information present in the EEG signal may not be visible for the human expert and any subtle variations hence cannot be observed and monitored as and when it occurs. Especially in the time series EEG data, subtle variations can not be perceived by human eye. In such a situation the computational approach becomes very important to extract any such micro variations in the EEG recording, containing significant information about the status of any pathology present. Also, since EEG is an inexpensive method and due to its portability, it can be used as a powerful mass screening tool. EEG signals are the signatures of neural activities. They are captured by multiple-electrode either invasively or non-invasively, over the cortex under the skull, or certain locations over the scalp, and can be recorded in different formats. The signals are normally presented in the time domain, but by applying simple signal processing tools such as the Fourier transform to perform frequency analysis and some imaging tools to visualize EEG topographies , the brain activities can be visualized in frequency or spatial domains respectively. Various time domain, frequency domain, time-frequency methods, statistical signal processing technique such as Wavelet transform [5], Recurrent Neural network [6], nonlinear systems [7], logistic regression [8], spectral densities of DWT coefficients [16], etc., and chaotic signal processing techniques [2] are used to study the pathology of brain such as epilepsy. These techniques are also used to classify between alcoholic, non-alcoholic and epilept ic subjects. In recent years, several research groups have started investigating the potential of electroencephalograms (EEGs) for detecting alcoholism and study the short term and long term effects on the brain. There have been many algorithms developed so far for processing EEG signals. Some of the operations include time-domain analysis, frequency-domain analysis, spatial-domain analysis, and multiway processing. Also, several algorithms have been developed to visualize the brain activity from images reconstructed from only the EEGs. Separation of the desired sources from the multisensor EEGs has been another research area. This can later lead to the detection of brain abnormalities such as epilepsy and the sources related to various physical and mental activities. In this section, some of the signal processing techniques applied to EEG signal for the detection of alcoholism is reviewed. A. Extraction of spectral band power and parametric methods Ong, Kok Mang et al, have shown that VEP (visually evoked potential) could be influenced by long term alcohol abuse [20]. The power spectral density of the recorded VEP was estimated using Burg algorithm (parametric analysis) and the extracted Gamma band power was used as features to train the neural network to classify the alcoholics and non-alcoholics. The authors claim that classification result of 97.50% accuracy has been achieved, to discriminate alcoholics from non-alcoholics.Kok-Meng Ong et al., have proposed Principal Component Analysis (PCA) method for the optimization of the selection of a subset of channels for single trial Visual Evoked Potentials (VEP) signals [23]. The proposed method was successful in optimizing a subset of channels that guaruntees high classification accuracy of alcoholics and non-alcoholics Another similar study by Ramaswamy Palaniappan et al., show that the difference of VEP signals between alcoholics and non-alcoholics can be observed using two spectral power ratios in gamma band (37-50 Hz) extracted from seven channels. This result implies that gamma band spectral power could be used as a biomarker on the lasting effects of long-term use of alcohol on visual response though the studied alcoholics have been abstinent for a minimum period of 1 month. Here Genetic algorithm (GA) is used to optimize the selection of subset of the feature set and classification is done with Fuzzy ARTMAP (FA) classifier [11], using VEP signals. The seven spectral bands of VEP signals are extracted using infinite impulse response (IIR) band-pass filters with constant gain and uniform bandwidth. Spectral power in these bands is calculated using Parsevals theorem and used as features to train the FA and ML-BP classifiers. The proposed technique discriminates alcoholics from non-alcoholics wit h high accuracy. In continuation of the previous work, Ramaswamy Palaniappan et al., in their work have derived second order autoregressive (AR) coefficients [21] to discriminate alcoholics using single trial gamma band Visual Evoked Potential (VEP) signals using 3 different classifiers: Simplified Fuzzy ARTMAP (SFA) neural network (NN), Multilayer-perceptron-back propagation (MLP-BP) NN and Linear Discriminant (LD) function . Here elliptic filtering was used in the gamma band spectral range on single trial VEP signals. The average classification errors of 2.6%, 2.8% and 11.9% were obtained from LD, MLP-BP and SFA classifiers. The high accuracy of LD classification results show the effectiveness of the proposed method to discriminate between alcoholic subjects and controls. Several improvements were proposed to previous work of automated classification of alcoholics and non-alcoholics [24] by the same author. In the previous paper, MLP-NN classifying energy of gamma band VEP signals gave the best cla ssification performance using 800 VEP signals from 10 alcoholics and 10 non-alcoholics. Here, the dataset was extended to include 3560 VEP signals from 102 subjects: 62 alcoholics and 40 non-alcoholic. The classification performance was improved by i) increasing the gamma band spectral range ii) Multiple Signal Classification algorithm was used to obtain the power of the dominant frequency in gamma band VEP signals for feature extraction iii) the use of the k nearest neighbour classifier. The performance was validated by a 10-fold cross validation classification. Modification resulted in an improvement in the classification percentage from 94.49% to 98.71% in maximum averaged CVC accuracy. In this paper by Ramaswamy Palaniappan [30], a method is proposed to discriminate chronic alcoholic from non-alcoholic subjects while the subjects were sober. Energies of EEG signals in multiple gamma bands were used as features while the subjects were asked to do a picture recognition task .A neural network was used for classifying chronic alcoholic subjects from controls. Leave one out cross validation strategy revealed that alcoholics could be discriminated from non-alcoholics with accuracy of 94.55%. This study shows that the energy in gamma band spectral energy can be used as a biomarker for screening of alcoholics. The classification of chronic alcoholics from non-alcoholics using the EEG is studied in this paper by A Shahina et al., [27].Weighted Linear Prediction Cepstral Coefficients were extracted from the VEP and used as discriminating feature vectors. Auto associative neural network was used to classify these vectors into alcoholics and non alcoholics. A recognition accuracy of 52.5% is achieved. This shows that all the 64 channels do not have the same discriminatory attributes causing a reduction in the accuracy levels. Hence the authors conclude that in order to improve the classification performance, there is a need for the optimization of the number of channels to be considered for classification. In this study by Tugce Balli et al., [31], they investigated the electrophysiological differences between alcoholic and control subjects using two different approaches namely complexity and energy analysis. The EEG data used in this study were recorded from 77 alcoholic and 44 control subjects while the subjects were performing delayed matching to sample object recognition task for three types of stimuli. The experimental paradigm evokes object recognition, visual short-term memory and decision making abilities. The results indicated that all regions (i.e. frontal, central, temporal, parietal and occipital) in the brain exhibit more complexity and less energy for alcoholic subjects as compared to controls. When different visual stimuli pairs were compared among alcoholic and control subjects, the results from energy analysis showed group wise differences in occipital and parietal regions. These results provide a strong indication on the impairment in brains electrophysiological activ ity for alcoholic subjects due to a history of long term alcohol abuse. Chronic alcoholism is classically associated with major deficits in the visual and auditory processing of emotions. However, the cross modal (auditory-visual) processing of emotional stimuli, which occurs most frequently in everyday life, has not yet been explored.

Provoking Revenge In Hamlet Essay example -- essays research papers

Storming into the palace and throwing accusations at Claudius, Laertes reveals he is impulsive. Laertes anger is due to the dishonor that has been inflicted on his family by Polonius’s murder. Claudius takes advantage of the sudden appearance of Laertes, by provoking Laertes into assisting him in plotting Hamlet’s murder. Shakespeare uses Laertes not only as a catalyst in the story, but as a contrast to the pensive Hamlet. Both men seek the same kind of justice but chose different paths to attain it. Laertes acts on anger without thinking, but Hamlet waits, debating the consequence of committing murder. Laertes function is to contrast Hamlet’s sensibility with his incensed spontaneity.Claudius manipulates to his advantage Laertes lack of hesitation and hot temper. Winning Laertes support by painting Hamlet as a malicious killer Claudius provokes Laertes to avenge Polonius. Claudius gives Laertes initiative to kill Hamlet saying for Hamlet’s "death no wind of blame shall breathe"(227) on the killer. Laertes is eager to "be the organ"(227) that aids Claudius in killing Hamlet, but to make sure Laertes is not "a face without a heart"(231) Claudius questions Laertes love for his father. This is Laertes breaking point. Laertes wants immediate action so that his "revenge will come"(225), not thinking of the consequence. His ability to ignore what will result from his revenge contrasts Hamlet’s turmoil over killing Claudius.Because Hamlet... Provoking Revenge In Hamlet Essay example -- essays research papers Storming into the palace and throwing accusations at Claudius, Laertes reveals he is impulsive. Laertes anger is due to the dishonor that has been inflicted on his family by Polonius’s murder. Claudius takes advantage of the sudden appearance of Laertes, by provoking Laertes into assisting him in plotting Hamlet’s murder. Shakespeare uses Laertes not only as a catalyst in the story, but as a contrast to the pensive Hamlet. Both men seek the same kind of justice but chose different paths to attain it. Laertes acts on anger without thinking, but Hamlet waits, debating the consequence of committing murder. Laertes function is to contrast Hamlet’s sensibility with his incensed spontaneity.Claudius manipulates to his advantage Laertes lack of hesitation and hot temper. Winning Laertes support by painting Hamlet as a malicious killer Claudius provokes Laertes to avenge Polonius. Claudius gives Laertes initiative to kill Hamlet saying for Hamlet’s "death no wind of blame shall breathe"(227) on the killer. Laertes is eager to "be the organ"(227) that aids Claudius in killing Hamlet, but to make sure Laertes is not "a face without a heart"(231) Claudius questions Laertes love for his father. This is Laertes breaking point. Laertes wants immediate action so that his "revenge will come"(225), not thinking of the consequence. His ability to ignore what will result from his revenge contrasts Hamlet’s turmoil over killing Claudius.Because Hamlet...

A Dolls House, Drama Analysis, Realism and Naturalism Essay

Nora Helmer frolics about in the first act, behaves desperately in the second, and gains a stark sense of reality during the finale of Henrik Ibsen’s A Doll’s House. Ibsen was one of a few pioneers of the new theatrical movement of realism, and accordingly he is often called the father of modern drama. The character of Nora lives in a dream world, a childlike fantasy, where everything is perfect, and everything makes sense, but as the play develops, Nora transforms and finds the strength to leave her home and her children in order to find out who she is and what she wants out of life. Nora leaves the role of the doll child and doll wife and becomes an independent self-thinking adult. She realizes that the world is different than she always thought it was, and that she herself is also different. The play opens a door onto the social problems that many face but never speak of. Since Ibsen’s time, women have made great strides in gaining the choice to determine thei r role in relation to the family and society. A Doll’s House uses the character of Nora Helmer to show the transformation that takes place from dependent house wife to independent adult. The theme of A Doll’s House, a woman’s right to individual self-fulfillment, was considered highly subversive in an age when women were not allowed to conduct business without the authority of a father or husband. Wives and daughters were considered to be property, thus lending to women acting childish and naive. The character of Nora exhibits many of these juvenile and immature qualities. The audience first sees her when she returns from a seemingly extravagant Christmas shopping excursion. She eats a few desserts which she has secretly purchased. When her condescending husband, Torvald Helmer, asks if she has been sneaking macaroons, she denies it whole-heartedly. The Narrator tells us, â€Å"She takes a bag of macaroons out of her pocket and eats one or two; then she walks stealthily across and listens at her husbandâ₠¬â„¢s door† (Ibsen 1681). With this minor act of deception, the audience learns that Nora is quite capable of lying. She is most child-like when she interacts with her husband. She behaves playfully yet obediently in his presence, always coaxing favors from him instead of communicating as equals. Torvald gently reprimands Nora throughout the play, and Nora good-naturedly responds to his criticism showing how immature and dependent she is. However, Nora has been leading a double life. She has not been thoughtlessly spending their money. Rather she has been scrimping and saving to pay off a secret debt. Years ago, when her husband became ill, Nora forged her father’s signature to receive a loan to save Torvald’s life. The fact that she never told Torvald about this arrangement reveals several aspects of her character. For one, the audience no longer sees Nora as the sheltered, care-free wife of a banker. She knows what it means to struggle and take risks. In addition, the act of concealing the ill -gotten loan signifies Nora’s independent streak as stated in the line, â€Å"Daddy never gave us a penny. I was the one who raised the money† (Ibsen 1688). She is proud of the sacrifice she has made. Although she says nothing to Torvald, she brags about her actions with her old friend Mrs. Linde. Basically, she believes that her husband would undergo just as many hardships, if not more, for her sake. However, her perception of her husband’s devotion is quite misplaced. Nora is evolving and is showing an independent side to her personality. When the disgruntled Krogstad threatens to reveal the truth about her forgery, Nora realizes that she has potentially brought scandal upon her husband’s good name. She begins to question her own morality, something she has never done before. Did she do something wrong? Was it not the right thing to do, under the circumstances? Will the courts convict her? Is she an improper wife? Is she a terrible mother? Nora contemplates suicide as a means to eliminate the dishonor she has wrought upon her family. She seems to lose all grasp of reality as she declares, â€Å"Never, never. Oh, that bla ck icy water. Oh, that bottomless†¦! If only it were all over! He’s got it now. Now he’s reading it† (Ibsen 1727). Yet, it remains debatable as to whether or not she would truly follow through and jump in the icy river. During the climactic scene in Act III, Nora seems to stall before running out into the night to end her life. Nora is frantic and changing into an adult by confronting the inevitable future that faces her. She realizes that it is always darkest before the dawn. Nora’s epiphany occurs when the truth is finally revealed. As Torvald unleashes his disgust towards Nora and her crime of forgery, the protagonist realizes that her husband is a very different person than she once believed. Torvald declairs, â€Å"I’m done for, a miserable failure, and it’s all the fault of a feather-brained woman† (Ibsen 1727). Torvald has no intention of taking the blame for Nora’s crime. She thought for certain that he would selflessly give up everything for her. When he fails to do this, she accepts the fact that their marriage has been an illusion. Their false devotio n has been merely play acting. She has been his â€Å"child-wife† and his â€Å"doll.† The monologue in which she calmly confronts Torvald serves as one of Ibsen’s finest moments. Some argue that Nora leaves her home purely because she is selfish. She does not want to forgive Torvald. She would rather start another life than try to fix her existing one. Or perhaps she feels that Torvald was right, that she is a child who knows nothing of the world. Since she knows so little about herself or society, she feels that she is an inadequate mother and wife. She leaves the children because she feels it is for their benefit, painful as it may be to her. Nora Helmer’s last words are hopeful, yet her final action is less optimistic. She leaves Torvald explaining that there is a slight chance they could become man and wife once again, but only if a â€Å"miracle of miracles† occurred. This gives Torvald a brief ray of hope. However, Nora exits through the hall door, symbolizing the finality of their relationship. Nora has reached her final breaking point and has evolved from childlike to mature and decisive. A Doll’s House, with its multi-level characters, opens a door onto real problems facing the most common of marriages. Although, Ibsen’s views differed from those held by many modern feminists, he firmly believed that women were inherently suited to being mothers and wives. However, he also felt that a husband and wife should live as equal partners, free to become their own human beings. The play shines a spotlight on problems that few women were willing to talk about. The so called perfect life of Nora Helmer in A Doll’s House highlights the changes from child to adult in a very short time and proves the point that it is never too late to change. Work Cited Ibsen, Henrik. A Doll’s House. Literature: An Introduction to Fiction, Poetry, Drama and Writing. Ed. Kennedy, X.J. and Dana Gioia. 10th ed., New York: Pearson Longman. 2007. 1679-1734. Print